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Simoa单分子免疫阵列超灵敏细胞因子
检测服务

产品介绍:

SimoaTM(Single Molecular Array)又称作数字式ELISA,是基于Simoa HD-1数字式单分子免疫阵列分析仪,可直接对血清和血浆中蛋白、核酸等生物标志物进行检测的技术。它的检测灵敏度比传统的免疫检测技术平均高1000倍以上,将蛋白质检测技术直接带入单分子、数字化检测时代,成为fg超低丰度蛋白质检测领域的优势技术。


技术原理:

1、将捕获抗体偶联到磁珠上,磁珠与目标抗原结合,目的抗原与检测抗体结合并带有梅标记。

2、洗涤磁珠以去除非特异性结合的蛋白,加入酶反应底物。

3、将加入底物的磁珠转入Simoa光盘上,将荧光信号封闭在小孔内。

 

应用领域:

Simoa技术可用于肿瘤、神经、感染性疾病、免疫炎症、miRNA检测,特别是癌症的早期检测、术后的监测和精准用药,将极大推动精准医疗的发展。运用Simoa可检测到的低浓度生物标志物进行准确分析,为生命科学研究、体外诊断、伴随诊断和血液筛查等领域。目前在全球引用该技术发表的文献有200多篇,包括高分杂志Nature, Nature Biotechnology, JEM, JAMA Neurology等。

参考文献

[1] Gill J, Merchant-Borna K, Jeromin A, et al. Acute plasma tau relates to prolonged return to play after concussion[J]. Neurology, 2017, 88: 595-602.

[2] Lin YS, Lee WJ, Wang SJ, et al. Levels of plasma neuroflament light chain and cognitive function in patients with Alzheimer or Parkinson disease[J],2018, Science Report, 2018, 8: 018-35766.

[3] Sokoll LJ, Zhang Z, Chan DW, et al. Do Ultrasensitive Prostate Specifc Antigen Measurements Have a Role in Predicting Long-Term Biochemical Recurrence-Free Survival in Men after Radical Prostatectomy?[J]. Journal of Urology, 2016, 195: 330-336.

[4] Byrne LM, Rodrigues FB, Blennow K, et al. Neuroflament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis[J]. Lancet Neurology, 2017, 16: 601-609.

[5] Mattsson N, Andreasson U, Zetterberg H,(2017) Association of Plasma Neuroflament Light With Neurodegeneration in Patients With Alzheimer Disease[J]. JAMA Neurology, 2017, 74: 557-566.

[6] Piehl F, Kockum I, Khademi M, et al. Plasma neuroflament light chain levels in patients with MS switching from injectable therapies to fngolimod[J]. Multiple Sclerosis Journal, 2018, 24: 1046-1054.

[7] Hansson O, Janelidze S, Hall S, et al. (2017) Blood-based NfL: A biomarker for differential diagnosis of parkinsonian disorder[J]. Neurology, 2017, 88: 930-937.

[8] Chen Z, Mengel D, Keshavan A, et al. Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease[J]. Alzheimers Dement, 2018, 9: 33561-33561.

[9] Yanamandra K, Patel TK, Jiang H, et al. Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy[J]. Science Translation Medicine. 2017, 9 (386):eaal2029.

[10] Kawata K, Mitsuhashi M, Aldret R. A Preliminary Report on Brain-Derived Extracellular Vesicle as Novel Blood Biomarkers for Sport-Related Concussions[J]. Frontiers Neurology, 2018, 9:239.


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